| Sept. 4, 2010 | MLS | 2010 | Chivas USA | 0 - 3 | Colorado Rapids | 10312 | 1 | ||
| Sept. 4, 2010 | MLS | 2010 | Philadelphia Union | 1 - 1 | Kansas City Wizards | 17182 | 1 | ||
| Sept. 4, 2010 | MLS | 2010 | Chicago Fire | 1 - 1 | Los Angeles Galaxy | 21068 | 1 | ||
| Sept. 4, 2010 | MLS | 2010 | Columbus Crew | 1 - 0 | D.C. United | 12075 | 1 | ||
| Sept. 4, 2010 | MLS | 2010 | New England Revolution | 3 - 1 | Seattle Sounders | 13124 | 1 | ||
| Sept. 4, 2010 | MLS | 2010 | FC Dallas | 1 - 0 | Toronto FC | 10033 | 1 | ||
| Sept. 4, 2010 | MLS | 2010 | New York Red Bulls | 0 - 1 | Real Salt Lake | 19115 | 1 |
| GP | W | T | L | gf | ga | gf/ga | |||
|---|---|---|---|---|---|---|---|---|---|
| Columbus Crew | MLS | 2010 | 23 | 13 | 5 | 5 | 32 | 20 | 1.60 |
| LA Galaxy | MLS | 2010 | 23 | 13 | 5 | 5 | 33 | 17 | 1.94 |
| Real Salt Lake | MLS | 2010 | 23 | 12 | 7 | 4 | 37 | 16 | 2.31 |
| New York Red Bulls | MLS | 2010 | 23 | 11 | 4 | 8 | 27 | 24 | 1.13 |
| FC Dallas | MLS | 2010 | 22 | 10 | 10 | 2 | 29 | 17 | 1.71 |
| Colorado Rapids | MLS | 2010 | 22 | 9 | 7 | 6 | 28 | 21 | 1.33 |
| Seattle Sounders | MLS | 2010 | 23 | 9 | 5 | 9 | 26 | 29 | 0.90 |
| New England Revolution | MLS | 2010 | 22 | 7 | 3 | 12 | 24 | 36 | 0.67 |
| Sporting Kansas City | MLS | 2010 | 22 | 7 | 6 | 9 | 22 | 24 | 0.92 |
| Toronto FC | MLS | 2010 | 22 | 7 | 6 | 9 | 22 | 26 | 0.85 |
| Chicago Fire | MLS | 2010 | 20 | 6 | 7 | 7 | 28 | 29 | 0.97 |
| Chivas USA | MLS | 2010 | 22 | 6 | 4 | 12 | 23 | 29 | 0.79 |
| Philadelphia Union | MLS | 2010 | 22 | 5 | 6 | 11 | 26 | 38 | 0.68 |
| D.C. United | MLS | 2010 | 23 | 4 | 3 | 16 | 15 | 37 | 0.41 |