| Sept. 25, 2010 | MLS | 2010 | Chivas USA | 0 - 3 | Philadelphia Union | 16481 | 1 | ||
| Sept. 25, 2010 | MLS | 2010 | San Jose Earthquakes | 3 - 2 | Toronto FC | 20064 | 1 | ||
| Sept. 25, 2010 | MLS | 2010 | D.C. United | 1 - 3 | Houston Dynamo | 13828 | 1 | ||
| Sept. 25, 2010 | MLS | 2010 | Columbus Crew | 2 - 2 | New England Revolution | 13533 | 1 | ||
| Sept. 25, 2010 | MLS | 2010 | Chicago Fire | 0 - 1 | Seattle Sounders | 17477 | 1 | ||
| Sept. 25, 2010 | MLS | 2010 | FC Dallas | 3 - 1 | Kansas City Wizards | 10385 | 1 | ||
| Sept. 25, 2010 | MLS | 2010 | Colorado Rapids | 1 - 1 | Real Salt Lake | 18317 | 1 |
| GP | W | T | L | gf | ga | gf/ga | |||
|---|---|---|---|---|---|---|---|---|---|
| Columbus Crew | MLS | 2010 | 26 | 13 | 6 | 7 | 35 | 29 | 1.21 |
| Real Salt Lake | MLS | 2010 | 26 | 13 | 9 | 4 | 39 | 17 | 2.29 |
| FC Dallas | MLS | 2010 | 26 | 11 | 13 | 2 | 36 | 22 | 1.64 |
| San Jose Earthquakes | MLS | 2010 | 24 | 11 | 6 | 7 | 28 | 25 | 1.12 |
| Seattle Sounders | MLS | 2010 | 26 | 11 | 6 | 9 | 31 | 29 | 1.07 |
| Colorado Rapids | MLS | 2010 | 25 | 10 | 8 | 7 | 33 | 25 | 1.32 |
| Sporting Kansas City | MLS | 2010 | 25 | 9 | 6 | 10 | 29 | 30 | 0.97 |
| Toronto FC | MLS | 2010 | 26 | 8 | 7 | 11 | 26 | 31 | 0.84 |
| Chivas USA | MLS | 2010 | 25 | 7 | 4 | 14 | 25 | 34 | 0.74 |
| Houston Dynamo | MLS | 2010 | 26 | 7 | 5 | 14 | 35 | 45 | 0.78 |
| New England Revolution | MLS | 2010 | 26 | 7 | 5 | 14 | 28 | 45 | 0.62 |
| Philadelphia Union | MLS | 2010 | 25 | 7 | 6 | 12 | 30 | 39 | 0.77 |
| Chicago Fire | MLS | 2010 | 24 | 6 | 8 | 10 | 28 | 32 | 0.88 |
| D.C. United | MLS | 2010 | 26 | 5 | 3 | 18 | 18 | 42 | 0.43 |