| Oct. 2, 2010 | MLS | 2010 | Seattle Sounders | 3 - 2 | Toronto FC | 36079 | 1 | ||
| Oct. 2, 2010 | MLS | 2010 | Houston Dynamo | 1 - 1 | Philadelphia Union | 16115 | 1 | ||
| Oct. 2, 2010 | MLS | 2010 | Columbus Crew | 0 - 0 | San Jose Earthquakes | 10867 | 1 | ||
| Oct. 2, 2010 | MLS | 2010 | New England Revolution | 1 - 2 | Real Salt Lake | 18130 | 1 | ||
| Oct. 2, 2010 | MLS | 2010 | New York Red Bulls | 1 - 0 | Kansas City Wizards | 24799 | 1 | ||
| Oct. 2, 2010 | MLS | 2010 | Chicago Fire | 0 - 3 | FC Dallas | 10615 | 1 | ||
| Oct. 2, 2010 | MLS | 2010 | Colorado Rapids | 0 - 1 | D.C. United | 15478 | 1 |
| GP | W | T | L | gf | ga | gf/ga | |||
|---|---|---|---|---|---|---|---|---|---|
| New York Red Bulls | MLS | 2010 | 27 | 14 | 5 | 8 | 35 | 27 | 1.30 |
| Real Salt Lake | MLS | 2010 | 27 | 14 | 9 | 4 | 41 | 18 | 2.28 |
| Columbus Crew | MLS | 2010 | 27 | 13 | 7 | 7 | 35 | 29 | 1.21 |
| FC Dallas | MLS | 2010 | 27 | 12 | 13 | 2 | 39 | 22 | 1.77 |
| Seattle Sounders | MLS | 2010 | 27 | 12 | 6 | 9 | 34 | 31 | 1.10 |
| Colorado Rapids | MLS | 2010 | 27 | 11 | 8 | 8 | 37 | 27 | 1.37 |
| San Jose Earthquakes | MLS | 2010 | 26 | 11 | 7 | 8 | 28 | 28 | 1.00 |
| Sporting Kansas City | MLS | 2010 | 26 | 9 | 6 | 11 | 29 | 31 | 0.94 |
| Toronto FC | MLS | 2010 | 27 | 8 | 7 | 12 | 28 | 34 | 0.82 |
| Chicago Fire | MLS | 2010 | 26 | 7 | 8 | 11 | 31 | 35 | 0.89 |
| Houston Dynamo | MLS | 2010 | 27 | 7 | 6 | 14 | 36 | 46 | 0.78 |
| New England Revolution | MLS | 2010 | 27 | 7 | 5 | 15 | 29 | 47 | 0.62 |
| Philadelphia Union | MLS | 2010 | 27 | 7 | 7 | 13 | 32 | 44 | 0.73 |
| D.C. United | MLS | 2010 | 27 | 6 | 3 | 18 | 19 | 42 | 0.45 |