| Oct. 16, 2010 | MLS | 2010 | Chicago Fire | 0 - 0 | D.C. United | 19056 | 1 | ||
| Oct. 16, 2010 | MLS | 2010 | Columbus Crew | 2 - 2 | Toronto FC | 18084 | 1 | ||
| Oct. 16, 2010 | MLS | 2010 | New York Red Bulls | 1 - 2 | Philadelphia Union | 18578 | 1 | ||
| Oct. 16, 2010 | MLS | 2010 | New England Revolution | 1 - 0 | Kansas City Wizards | 18298 | 1 | ||
| Oct. 16, 2010 | MLS | 2010 | FC Dallas | 0 - 2 | Real Salt Lake | 20236 | 1 | ||
| Oct. 16, 2010 | MLS | 2010 | Houston Dynamo | 1 - 0 | San Jose Earthquakes | 10597 | 1 | ||
| Oct. 16, 2010 | MLS | 2010 | Colorado Rapids | 3 - 1 | Los Angeles Galaxy | 27000 | 1 |
| GP | W | T | L | gf | ga | gf/ga | |||
|---|---|---|---|---|---|---|---|---|---|
| LA Galaxy | MLS | 2010 | 29 | 17 | 5 | 7 | 42 | 25 | 1.68 |
| Real Salt Lake | MLS | 2010 | 29 | 15 | 10 | 4 | 43 | 18 | 2.39 |
| New York Red Bulls | MLS | 2010 | 29 | 14 | 6 | 9 | 36 | 29 | 1.24 |
| Columbus Crew | MLS | 2010 | 29 | 13 | 8 | 8 | 37 | 33 | 1.12 |
| Colorado Rapids | MLS | 2010 | 29 | 12 | 9 | 8 | 42 | 30 | 1.40 |
| FC Dallas | MLS | 2010 | 29 | 12 | 14 | 3 | 41 | 26 | 1.58 |
| San Jose Earthquakes | MLS | 2010 | 28 | 12 | 7 | 9 | 30 | 29 | 1.03 |
| Sporting Kansas City | MLS | 2010 | 29 | 10 | 6 | 13 | 32 | 34 | 0.94 |
| New England Revolution | MLS | 2010 | 29 | 9 | 5 | 15 | 32 | 48 | 0.67 |
| Chicago Fire | MLS | 2010 | 29 | 8 | 9 | 12 | 33 | 37 | 0.89 |
| Houston Dynamo | MLS | 2010 | 29 | 8 | 6 | 15 | 38 | 48 | 0.79 |
| Philadelphia Union | MLS | 2010 | 29 | 8 | 7 | 14 | 34 | 46 | 0.74 |
| Toronto FC | MLS | 2010 | 29 | 8 | 8 | 13 | 30 | 39 | 0.77 |
| D.C. United | MLS | 2010 | 29 | 6 | 4 | 19 | 19 | 44 | 0.43 |