| Sept. 18, 2010 | MLS | 2010 | Chicago Fire | 0 - 1 | Real Salt Lake | 14440 | 1 | ||
| Sept. 18, 2010 | MLS | 2010 | Columbus Crew | 0 - 4 | Seattle Sounders | 17144 | 1 | ||
| Sept. 18, 2010 | MLS | 2010 | Houston Dynamo | 1 - 2 | Toronto FC | 16435 | 1 | ||
| Sept. 18, 2010 | MLS | 2010 | Colorado Rapids | 3 - 0 | New England Revolution | 16314 | 1 | ||
| Sept. 18, 2010 | MLS | 2010 | D.C. United | 1 - 2 | Los Angeles Galaxy | 20094 | 1 |
| GP | W | T | L | gf | ga | gf/ga | |||
|---|---|---|---|---|---|---|---|---|---|
| LA Galaxy | MLS | 2010 | 25 | 15 | 5 | 5 | 38 | 19 | 2.00 |
| Columbus Crew | MLS | 2010 | 25 | 13 | 5 | 7 | 33 | 27 | 1.22 |
| Real Salt Lake | MLS | 2010 | 25 | 13 | 8 | 4 | 38 | 16 | 2.38 |
| Colorado Rapids | MLS | 2010 | 24 | 10 | 7 | 7 | 32 | 24 | 1.33 |
| Seattle Sounders | MLS | 2010 | 25 | 10 | 6 | 9 | 30 | 29 | 1.03 |
| Toronto FC | MLS | 2010 | 25 | 8 | 7 | 10 | 24 | 28 | 0.86 |
| New England Revolution | MLS | 2010 | 24 | 7 | 3 | 14 | 24 | 41 | 0.59 |
| Chicago Fire | MLS | 2010 | 23 | 6 | 8 | 9 | 28 | 31 | 0.90 |
| Houston Dynamo | MLS | 2010 | 24 | 6 | 5 | 13 | 29 | 40 | 0.73 |
| D.C. United | MLS | 2010 | 25 | 5 | 3 | 17 | 17 | 39 | 0.44 |