| Oct. 23, 2010 | MLS | 2010 | Houston Dynamo | 2 - 1 | Seattle Sounders | 23990 | 1 | ||
| Oct. 23, 2010 | MLS | 2010 | D.C. United | 2 - 3 | Toronto FC | 18071 | 1 | ||
| Oct. 23, 2010 | MLS | 2010 | San Jose Earthquakes | 1 - 4 | Kansas City Wizards | 11518 | 1 | ||
| Oct. 23, 2010 | MLS | 2010 | Colorado Rapids | 2 - 2 | Real Salt Lake | 17729 | 1 | ||
| Oct. 23, 2010 | MLS | 2010 | Chicago Fire | 4 - 1 | Chivas USA | 14825 | 1 |
| GP | W | T | L | gf | ga | gf/ga | |||
|---|---|---|---|---|---|---|---|---|---|
| Real Salt Lake | MLS | 2010 | 30 | 15 | 11 | 4 | 45 | 20 | 2.25 |
| Seattle Sounders | MLS | 2010 | 30 | 14 | 6 | 10 | 39 | 35 | 1.11 |
| San Jose Earthquakes | MLS | 2010 | 30 | 13 | 7 | 10 | 34 | 33 | 1.03 |
| Colorado Rapids | MLS | 2010 | 30 | 12 | 10 | 8 | 44 | 32 | 1.38 |
| Sporting Kansas City | MLS | 2010 | 30 | 11 | 6 | 13 | 36 | 35 | 1.03 |
| Chicago Fire | MLS | 2010 | 30 | 9 | 9 | 12 | 37 | 38 | 0.97 |
| Houston Dynamo | MLS | 2010 | 30 | 9 | 6 | 15 | 40 | 49 | 0.82 |
| Toronto FC | MLS | 2010 | 30 | 9 | 8 | 13 | 33 | 41 | 0.80 |
| Chivas USA | MLS | 2010 | 30 | 8 | 4 | 18 | 31 | 45 | 0.69 |
| D.C. United | MLS | 2010 | 30 | 6 | 4 | 20 | 21 | 47 | 0.45 |